Transcriptional control of lymphatic endothelial cell type specification.
Identifieur interne : 002382 ( Main/Exploration ); précédent : 002381; suivant : 002383Transcriptional control of lymphatic endothelial cell type specification.
Auteurs : Ying Yang [États-Unis] ; Guillermo OliverSource :
- Advances in anatomy, embryology, and cell biology [ 0301-5556 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Cellules endothéliales (cytologie), Différenciation cellulaire, Facteurs de transcription Forkhead (métabolisme), Lymphangiogenèse, Plan d'organisation du corps, Protéines suppresseurs de tumeurs (métabolisme), Protéines à homéodomaine (métabolisme), Régulation de l'expression des gènes au cours du développement, Transcription génétique, Vaisseaux lymphatiques (cytologie), Vaisseaux lymphatiques (embryologie).
- MESH :
- cytologie : Cellules endothéliales, Vaisseaux lymphatiques.
- embryologie : Vaisseaux lymphatiques.
- métabolisme : Facteurs de transcription Forkhead, Protéines suppresseurs de tumeurs, Protéines à homéodomaine.
- Animaux, Différenciation cellulaire, Lymphangiogenèse, Plan d'organisation du corps, Régulation de l'expression des gènes au cours du développement, Transcription génétique.
English descriptors
- KwdEn :
- Animals, Body Patterning, Cell Differentiation, Endothelial Cells (cytology), Forkhead Transcription Factors (metabolism), Gene Expression Regulation, Developmental, Homeodomain Proteins (metabolism), Lymphangiogenesis, Lymphatic Vessels (cytology), Lymphatic Vessels (embryology), Transcription, Genetic, Tumor Suppressor Proteins (metabolism).
- MESH :
- chemical , metabolism : Forkhead Transcription Factors, Homeodomain Proteins, Tumor Suppressor Proteins.
- cytology : Endothelial Cells, Lymphatic Vessels.
- embryology : Lymphatic Vessels.
- Animals, Body Patterning, Cell Differentiation, Gene Expression Regulation, Developmental, Lymphangiogenesis, Transcription, Genetic.
Abstract
The lymphatic vasculature is the "sewer system" of our body as it plays an important role in transporting tissue fluids and extravasated plasma proteins back to the blood circulation and absorbs lipids from the intestinal tract. Malfunction of the lymphatic vasculature can result in lymphedema and obesity. The lymphatic system is also important for the immune response and is one of the main routes for the spreading of metastatic tumor cells. The development of the mammalian lymphatic vasculature is a stepwise process that requires the specification of lymphatic endothelial cell (LEC) progenitors in the embryonic veins, and the subsequent budding of those LEC progenitors from the embryonic veins to give rise to the primitive lymph sacs from which the entire lymphatic vasculature will eventually be derived. This process was first proposed by Florence Sabin over a century ago and was recently confirmed by several studies using lineage tracing and gene manipulation. Over the last decade, significant advances have been made in understanding the transcriptional control of lymphatic endothelial cell type differentiation. Here we summarize our current knowledge about the key transcription factors that are necessary to regulate several aspects of lymphatic endothelial specification and differentiation.
DOI: 10.1007/978-3-7091-1646-3_2
PubMed: 24276883
Affiliations:
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Le document en format XML
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xml:lang="en"><term>Animals</term><term>Body Patterning</term><term>Cell Differentiation</term><term>Endothelial Cells (cytology)</term><term>Forkhead Transcription Factors (metabolism)</term><term>Gene Expression Regulation, Developmental</term><term>Homeodomain Proteins (metabolism)</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels (cytology)</term><term>Lymphatic Vessels (embryology)</term><term>Transcription, Genetic</term><term>Tumor Suppressor Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales (cytologie)</term><term>Différenciation cellulaire</term><term>Facteurs de transcription Forkhead (métabolisme)</term><term>Lymphangiogenèse</term><term>Plan d'organisation du corps</term><term>Protéines suppresseurs de tumeurs (métabolisme)</term><term>Protéines à homéodomaine (métabolisme)</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Transcription génétique</term><term>Vaisseaux lymphatiques (cytologie)</term><term>Vaisseaux lymphatiques (embryologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Forkhead Transcription Factors</term><term>Homeodomain Proteins</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Lymphatic Vessels</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription Forkhead</term><term>Protéines suppresseurs de tumeurs</term><term>Protéines à homéodomaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Body Patterning</term><term>Cell Differentiation</term><term>Gene Expression Regulation, Developmental</term><term>Lymphangiogenesis</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Différenciation cellulaire</term><term>Lymphangiogenèse</term><term>Plan d'organisation du corps</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Transcription génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic vasculature is the "sewer system" of our body as it plays an important role in transporting tissue fluids and extravasated plasma proteins back to the blood circulation and absorbs lipids from the intestinal tract. Malfunction of the lymphatic vasculature can result in lymphedema and obesity. The lymphatic system is also important for the immune response and is one of the main routes for the spreading of metastatic tumor cells. The development of the mammalian lymphatic vasculature is a stepwise process that requires the specification of lymphatic endothelial cell (LEC) progenitors in the embryonic veins, and the subsequent budding of those LEC progenitors from the embryonic veins to give rise to the primitive lymph sacs from which the entire lymphatic vasculature will eventually be derived. This process was first proposed by Florence Sabin over a century ago and was recently confirmed by several studies using lineage tracing and gene manipulation. Over the last decade, significant advances have been made in understanding the transcriptional control of lymphatic endothelial cell type differentiation. Here we summarize our current knowledge about the key transcription factors that are necessary to regulate several aspects of lymphatic endothelial specification and differentiation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><noCountry><name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name></noCountry><country name="États-Unis"><region name="Tennessee"><name sortKey="Yang, Ying" sort="Yang, Ying" uniqKey="Yang Y" first="Ying" last="Yang">Ying Yang</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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